BSV BioScience GmbH developed all technologies for API and finished dosage forms in its own R&D facilities. Currently we produce the following products:
Streptokinase is a protein derived from various streptococci which combines with plasminogen to form a complex activating plasminogen into the proteolytic enzyme plasmin. It is administered intravenously, to dissolve thrombi in patients with myocardial infarction, pulmonary embolism and other thrombo-embolic occlusion of veins and arteries, usually in combination with aspirin and other anticoagulants.
Urokinase is a double-chain protein, derived from human urine. Urokinase has the capability to convert plasminogen into plasmin. This protease (peptidase) is widely used for the treatment of acute heart attack, deep vein thrombosis, pulmonary embolism and heart catheter cleaning.
Human Chorionic Gonadotrophin (HCG) is produced in the organism during gestation and is responsible for stimulating continued steroid hormone secretion by the corpus luteum. The structure of the HCG is similar to the pituitary hormones LH, FSH and TSH. Only differences in the beta-subunit allow specific determination. HCG is a sialoglycoprotein with a molecular weight of 46,000 dalton. It is isolated from the collected urine of pregnant women. HCG is used in infertility treatments, in order to induce ovulation.
Human Menopausal Gonadotropin is a combination of the two pituitary gonadotropic hormones ‘Follicle Stimulating Hormone’ and ‘Luteinizing Hormone’. The proportion is approximately 1:1. The hormones are secreted by pituitary glands together with thyroid stimulating hormone. The molecular weight of each of these glycoprotein hormones is approx. 32,000 dalton, with each subunit having a molecular weight of 16,000 dalton. Tonic or basal levels of LH act in conjunction with FSH to induce estrogen secretion from the large Graafian follicle. HMG is used to stimulate the growth of follicles during infertility treatment.
Urofollitropin is a glycoprotein and belongs to the group of the pituitary gonadotropic hormones ‘Follicle Stimulating Hormone’. ‘Luteinizing Hormon´ is almost completely removed by chromatographic techniques. The proportion is approximately 60:1 The hormones are secreted by pituitary glands together with a thyroid stimulating hormone. The molecular weight of each of these glycoprotein hormones is approx. 32,000 dalton, with each sub-unit having a molecular weight of 16,000 dalton. Urofollitropin is produced by removing LH from menopausal gonadotropin.
Ulinastatin (urinary trypsin inhibitor, UTI) is found in human urine or blood. It is a glycosylatedprotein, having trypsin inhibiting activity. Apart from trypsin, Ulinastatin inhibits other serine proteases like α-chymotrypsin, leucocyte elastase and plasmin.