Urofollitropin, also known as Follicle Stimulating Hormone (FSH), is a glycoprotein hormone secreted by the gonadotrophs in the anterior pituitary gland. The major function of FSH is to promote and sustain the ovarian follicular growth in female and spermatogenesis in male.
FSH is a member of the glycoprotein hormone family which also includes LH, Human Chorionic Gonadotrophin (HCG) and the Thyroid Stimulating Hormone (TSH). These hormones are heterodimeric proteins comprising a common α-subunit and a unique β-subunit which confers the biological specificity to each hormone. FSH has a molecular weight of 32 kDa.
FSH is used within the scope of assisted reproductive technologies (ART).
HMG (Human Menopausal Gonadotrophin) is indicated in Hypogonadotrophic hypopituitarism (WHO Group I patients) where both gonadotropin stimulations are needed. In patients showing normal or high LH levels (WHO Group II patients), require preparations without LH activity, this character belongs to FSH.
FSH stimulates both the growth and maturation of follicles; it induces secretion of oestrogens and proliferation of the endometrium.
FSH and Human Chorionic Gonadotrophin (HCG) given in a sequential manner are indicated for induction of ovulation in patients with Polycystic Ovarian Disease (PCOD) who have evaluated LH/FSH ratio and who have failed to respond to adequate clomiphene citrate therapy.
They are used to stimulate the development of multiple oocytes in ovulatory patients participating in an in vivo fertility program. Further it is given to assist in the intrauterine insemination (IUI) treatment and in the vitro fertilization (IVF) technique.